The 2022 Audi S5 is available as a 2-door, 4-seat coupe. Starting at $55,300, the 2022 Audi S5 quattro Coupe is powered by a 3.0LL , 6 -cylinder engine mated to an automatic transmission that returns an EPA estimated 21-mpg in the city and 30-mpg on the highway. The top of the line 2022AudiS5quattro Sportback , priced at $ 55,300 , is powered by a 3.0LL , 6 - cylinder engine mated to an automatic transmission that returns an EPA estimated 21-mpg in the city and 30-mpg on the highway.