The 2012 Audi S5 is available as a 2-door, 4-seat coupe. Starting at $53,900, the 2012 Audi S5 Premium Plus (M6) quattro Coupe is powered by a 4.2L , 8 -cylinder engine mated to a manual transmission that returns an EPA estimated 14-mpg in the city and 22-mpg on the highway. The top of the line 2012AudiS5Special Edition (Tiptronic) quattro Coupe , priced at $ 69,900 , is powered by a 4.2L , 8 - cylinder engine mated to an automatic transmission that returns an EPA estimated 16-mpg in the city and 24-mpg on the highway.