The 2000 Isuzu Hombre is a 2-door, 3-seat Regular Side, available in 15 trims, ranging from the S (M5) 4x2 Regular Cab to the XS (A4) 4x4 Space Cab. Upon introduction, the $11,360 S (M5) 4x2 Regular Cab is equipped with a standard 2.2L, 4-cylinder, engine that achieves 23-mpg in the city and 29-mpg on the highway. a Manual transmission is standard. The $22,210 XS (A4) 4x4 Space Cab is equipped with a standard 4.3L, 6-cylinder, engine that achieves 16-mpg in the city and 21-mpg on the highway. an Automatic transmission is standard.